Distribution of Epstein–Barr Virus LMP1 Variants in Patients with Infectious Mononucleosis and Association with Selected Biochemical and Hematological Parameters

The molecular diversity of Epstein–Barr virus (EBV) is exceptionally complex and based on the characterization sequences coding for several viral genes. aim this study was to analyze distribution EBV types 1 2 characterize LMP1 variants in a cohort 73 patients with infectious mononucleosis (IM), as well investigate possible association between relevant clinical parameters. Population-based sequencing EBNA-2 gene showed presence type all IM patients. Analysis found restricted repertoire predominance wild-type B95-8, China1, Mediterranean North Carolina more than one variant 16.4% Co-infections different were associated significantly higher levels C-reactive protein lower maximal neutrophil counts minimal platelet count. results have shown narrow an exclusive from Croatia, suggesting characteristic local pattern virus. importance distinct immunobiological features co-infections needs be investigated further.